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During that time, the development of a distinct zona reticularis is accompanied by an extreme increase in the adrenal androgen precursor production due to the decreased expression of HSD3B2 in conjunction with increased CYB5A expression [[34], [35], [36], [37], [38]]

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These changes can lower the threshold for pathogenic syn misfolding and aggregation, thereby exacerbating neurodegeneration [33]

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The dosing protocols circulating on biohacker forums, one to two milligrams a day, five days on, two off, cycled monthly, come from animal extrapolations and individual physician case logs

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Jin Q, Yao C, Bian Y, Pi J

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Simultaneously, dopamine levels increased significantly from 29.17 6.39 ng/g in PD rats to 102.31 7.51 ng/g after treatment, though they remained below the control group level (135.90 9.21 ng/g)

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